Clinical Studies
The following are links to independently published clinical studies and medical research validating the effectiveness of many key ingredients found in our treatment formulations.
green tea/white tea
niacinamide
hyaluronic acid
licorice
azelaic acid/azeloyl glycine
urea
silymarin - milk thistle
glycerin/glycerol
tea tree
ceramides
sulfur
selenium
allantoin
dexpanthenol (B5)
Links
green tea / white tea
Cutaneous photoprotection from ultraviolet injury by green tea polyphenols
Cancer-Preventive Potential Of White Tea - Study Finds Rare Tea May Be Healthiest of All
New Study Shows Tea Extract Protects Skin; White Tea Extract Reveals Anti-cancer, Anti-aging
White Tea Beats Green Tea at Killing Germs
White tea - Wikapedia
niacinamide
Niacinamide - article by Dr. Leslie S. Baumann - Skin & Allergy News
Niacinamide and Moisturizers
Alleviating sensitivity - Study finds moisturizers with niacinamide make skin more resilient
Topical niacinimide reduces sallowness- Therapy also improves appearance of facial skin texture, fine
Niacinamide renewal Active form of vitamin B3 increases levels of NADPH in fight against aging skin
Nicotinic acid/niacinamide and the skin.
Niacinamide: A B vitamin that improves aging facial skin appearance.
The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer.
Nicotinamide increases biosynthesis of ceramides as well as other stratum corneum lipids to improve the epidermal permeability barrier.
hyaluronic acid
Hyaluronic acid: a unique topical vehicle for the localized delivery of drugs to the skin
Cosmeceutical Critique: Hyaluronic Acid - article by Dr. Leslie S. Baumann - Skin & Allergy News
licorice
Licorice Part 1 - article by Dr. Leslie S. Baumann - Skin & Allergy News
Dermatitis and licorice extract (glycyrrhizinic acid)
azelaic acid / azeloyl glycine
Azelaic acid - pharmaceutical info
Azelaic acid therapy for acne
Acne therapy with topical benzoyl peroxide, antibiotics and azelaic acid
Azelaic acid 15% gel in the treatment of acne vulgaris. Combined results of two double-blind clinical comparative studies
Azeloyl Glycine - The Benefits of the New Azelaic Acid Derivative
Clinical - Azeloyl Glycine: A new active in skin disequilibrium
urea
Topical urea in dermatology.
Urea-containing moisturizers influence barrier properties of normal skin
A double-blind comparison of two creams containing urea as the active ingredient. Assessment of efficacy and side-effects by non-invasive techniques and a clinical scoring scheme.
Urea - Wikepedia information.
hydrating effects of urea and glycerol on the stratum corneum when applied in basic formulations for external use
silymarin - milk thistle
Silymarin - article by Dr. Leslie S. Baumann - Skin & Allergy News
Urea-containing moisturizers influence barrier properties of normal skin
Silymarin inhibits UV radiation-induced immunosuppression through augmentation of interleukin-12 in mice
A Flavonoid Antioxidant, Silymarin, Affords Exceptionally High Protection against Tumor Promotion in the SENCAR Mouse Skin Tumorigenesis Model
Treatment of silymarin, a plant flavonoid, prevents ultraviolet light-induced immune suppression and oxidative stress in mouse skin
glycerin / glycerol
Glycerol - article by Dr. Leslie S. Baumann - Skin & Allergy News
Glycerol cream study - Skin Res Technol 2006; 12(1): 60-67
A double-blind study comparing the effect of glycerin and urea on dry, eczematous skin in atopic patients.
Glycerin May Help Skin Disease, Study Finds
tea tree
A comparative study of tea-tree oil versus benzoylperoxide in the treatment of acne.
Tea Tree Oil Treats Skin Problems
Tea Tree - article by Dr. Leslie S. Baumann - Skin & Allergy News
ceramides
Effect of a lipid-rich emollient containing ceramide 3 in experimentally induced skin barrier dysfunction.
The effect of a synthetic ceramide-2 on transepidermal water loss after stripping or sodium lauryl sulfate treatment: an in vivo study
sulfur
The use of sulfur in dermatology.
Acne and its management beyond the age of 35 years.
selenium
Selenium - article by Dr. Leslie S. Baumann - Skin & Allergy News
allantoin
Allantoin - article by Dr. Leslie S. Baumann - Skin & Allergy News
dexpanthenol (B5)
Efficacy of dexpanthenol in skin protection against irritation: a double-blind, placebo-controlled study
Dexpanthenol cream significantly improves mucocutaneous side effects associated with isotretinoin therapy
Cosmeceutical Critique: Dexpanthenol - article by Dr. Leslie S. Baumann - Skin & Allergy News
Topical use of dexpanthenol in skin disorders.
Effect of topically applied dexpanthenol on epidermal barrier function and stratum corneum hydration. Results of a human in vivo study.
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